Many drug-related deaths, particularly those resulting from opioid overdoses, have contributed to a reduction in life expectancy among Americans for the second year in a row in 2016, in an unprecedented
A collection of studies published in 2015 in the journal Innovations in Clinical Neuroscience cited research performed in the United States, which revealed that surveys conducted during 2006 and 2007, 20-35 percent of participants acknowledged the misuse of buprenorphine. The studies cited also examined 129 admissions to an outpatient-based narcotics treatment program and found that 49 percent of participants illicitly used buprenorphine in the past 90 days.
The method of misuse is commonly intranasal (snorting) or through injection, the latter of which can cause infectious complications or death.
Another common misconception about buprenorphine is that it’s a quick fix.
“We know that [buprenorphine, when used] short term, is not as effective,” said Dr. Mitra Ahadpour, director of the division of pharmacological therapies at the Substance Abuse and Mental Health Services Administration. “Patients that are placed on buprenorphine, and then detoxified of it rapidly between a few weeks, we found that retention is not great — those individuals go back to using illicit or opioid medication misuse.”
The side effects
Major side effects of buprenorphine include blurred vision, confusion, difficulty breathing, dizziness, faintness, drowsiness, pinpoint pupils, unusual fatigue, pale or blue lips, fingernails or skin, relaxed or calm feelings, and lightheadedness when standing from a lying or sitting position.
In addition, there are some common minor side effects including back pain, headache, nausea, stuffy or running nose, fever or chills, coughing, sneezing, stomach pain, vomiting, insomnia, constipation, and painful or difficult urination.
Less common minor side effects include diarrhea, sweating, faintness, lack or loss or strength, a sensation of warmth or heat, and redness in skin tone around the face and neck.
Withdrawal occurs because the body is attempting to heal from a consistent and extensive use of buprenorphine and the severity of withdrawal symptoms varies depending on the length and method of use.
Buprenorphine releases distinctive chemicals throughout the brain and body, and those chemicals are needed for day-to-day functioning when a patient becomes dependent.
Once a patient gets off buprenorphine, the brain may stop producing those natural chemicals, which leaves a void in the way it functions.
This is when withdrawal symptoms including nausea, vomiting, diarrhea, confusion, insomnia, anxiety, mood swings, irritability, abdominal pain, restlessness, excessive sweating, insomnia, and flu-like symptoms can begin to kick in.
One of the more serious withdrawal symptoms of buprenorphine is pulmonary aspiration — when vomit is accidentally inhaled into the lungs. Although this symptom may cause little to no harm, it could also lead to pneumonia or death from asphyxiation. Dehydration can also occur, and if left untreated can become deadly.
Underlying mental disorders, like depression or bipolar disorder, can also worsen during the withdrawal period, and relapse is the most common complication.
Typically, withdrawal can begin shortly following the last dose and can peak within the span of two to five days.
Withdrawal symptoms can also become overwhelming, which can route patients back to buprenorphine abuse and possibly to severe addiction.